This is US Highway 60, from Charleston to White Sulphur Springs.
This road has it all. This road will take you over the Appalachian Mountains. From Charleston, you are following the Kanawha River. Enjoy the falls near Glen Ferris. Many of the towns in this area are very narrow, and right up to the river. As you go further east, you are climbing into the mountains, and the road is narrow and has many switchbacks. There are several overlooks, such as Hawk's Nest, to look over the river valley.
The road is has many steep grades, where speed is not your friend. Ride with your lower gears, and enjoy the ride. Be more cautious when the road is wet as the coal dust can make the roads slippery, especially at the switchbacks. There are many switchbacks, and narrow in places. This is a mountain road. Lots of truck traffic as this timber and mining area.
There are many towns along this road, all with their own charm. One needs to stop at several to enjoy what they offer. Hawk's Nest is a great stop to overlook the valley. Bring your camera, you will want to take many pictures.