Written Directions
Start in Vicksburg, MS and Head North on Hwy 61 toward Memphis, TN. Music and good food is everywhere you look.
It may be worth diverting onto Hwy 1 for a bit by taking route 444 South of Clarksdale to go through Rosedale on to Greenville and then take hwy 82 back to hwy 61 in Leland (birthplace of Kermit the Frog).
https://travel.nationalgeographic.com/travel/road-trips/blues-highway-road-trip/
Scenery
The Mississippi Delta is flat with lots of fields and there will be long stretches where you can see for miles of corn, soybeans or cotton. Some places will be deep bayous with cypress tress, like an oasis in a sea of cotton fields. If you stay on Hwy 61, the ride if fairly easy and towns few and far between. Going off course may be some of the most interesting detours - you may find towns such as Midnight, Mississippi. The route I plan to show on the map goes off Hwy 61 for some scenery and attractions. The deer herds around Eagle Lake are rumored to be in the hundreds - especially when the Mississippi River is high.
Drive Enjoyment
230 miles, the road varies by county and main use. This road sees a lot of heavy machinery when the cotton harvest kicks in, so it is well used and often patched.
Tourism Opportunities
Fuel up in cities as there are not a lot of them and there is a good bit of road between them. There are a TON of attractions, hotels, restaurants and entertainment in Clarksdale, Tunica, Greenville, Greenwood and Memphis.https://travel.nationalgeographic.com/travel/road-trips/blues-highway-road-trip/